An allogeneic stem cell transplant utilizes healthy blood stem cells from a donor to replace the diseased or damaged bone marrow. An allogeneic stem cell transplant is also known as an allogeneic bone marrow transplant. The donor in this type of operation can be a family member, an acquaintance, or an unknown person. The blood stem cells utilized in an allogeneic stem cell transplant could be:
- Gathered from the donor’s blood
- Gathered from the bone marrow within the donor’s hipbone
- Gathered from the blood of a donated umbilical cord
Before receiving the transplant, the patient will receive high doses of chemotherapy or radiation for destroying the diseased cells and prepare the body for the donor cells.
Allogeneic BMT can be a choice for people with a wide range of cancerous and noncancerous diseases, like acute leukaemia, adrenoleukodystrophy, aplastic anaemia, chronic leukaemia, etc. BGS Gleneagles Global Hospitals has some of the best surgeons for allogeneic bone marrow transplant in Bangalore. The different types of allogeneic transplants based on the source of stem cells include:
- Allogeneic BMT using related donor: Here, the stem cells are extracted from a relative.
- Allogeneic BMT using matched unrelated donor: Here, the donor is searched by doctors from an international registry.
- Allogeneic BMT using haploidentical donors: The procedure utilizes HLA half-matched (haplotype) donors like biological parents, children, or half-matched siblings.
- Allogeneic transplant using the blood of umbilical cord: Here, the blood cells are extracted from the umbilical cord of a new born baby.
- Reduced-Intensity conditioning allogeneic transplants: This is an option for patients who can’t endure a full-intensity or myeloablative allogeneic transplant.
The following procedures collect the stem cells
- Peripheral blood stem cells: They are gathered by a process called apheresis. This takes place in the therapeutic apheresis outpatient unit. During the procedure, blood from a large vein goes through a central venous catheter, to a cell separation machine. The peripheral blood stem cells are collected, and the remaining blood is returned.
- Bone Marrow Harvest: In this procedure, a small portion of bone marrow is collected by a needle that goes through the skin, inside the marrow cavity of the hip bone.
The side effects of this type of transplant include increased risk of infections, excessive bleeding, graft-versus-host disease, etc. The hospital has one of the best doctors for allogeneic bone marrow transplant in Bangalore.